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ea0084op-03-16 | Oral Session 3: Advanced Thyroid Cancer | ETA2022

A clinical and molecular study of a real-world cohort of braf v600e anaplastic thyroid carcinoma treated with dabrafenib and trametinib

Nunes da Silva Tiago , Rodrigues Ricardo , Rito Miguel , Saramago Ana , Pires Carolina , Horta Mariana , Leite Valeriano , Cavaco Branca

Introduction and objectives: Anaplastic thyroid cancer (ATC) has a very low overall survival (OS) and progression free survival (PFS) due to fast growth and resistance to non-target therapies. A recent phase II study showed a dramatic increase in OS and PFS of BRAF V600E mutated ATC patients treated with Dabrafenib and Trametinib (DT). However as commonly reported in melanoma durable responses in ATC may be compromised by resistance mechanisms. Until now only a few ca...

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ea0049ep704 | Obesity | ECE2017

Elevated serum adiponectin in Alzheimer’s disease as neuroprotective strategy

Letra Liliana , Rodrigues Tiago , Matafome Paulo , Duro Diana , Lemos Raquel , Patricio Miguel , Castelo-Branco Miguel , Baldeiras Ines , Seica Raquel , Santana Isabel

Background: Several studies have highlighted the contribution of adipose tissue dysfunction to the development and progression of Alzheimers Disease (AD), which may depend on alterations in adipokine secretion. Leptin and adiponectin are the most abundant adipokines in circulation, with recognized systemic effects, but also able to cross the blood-brain barrier and influence cognitive-related structures, such as the hippocampus.Objective: To determ...

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Endocrine Abstracts

A clinical and molecular study of a real-world cohort of braf v600e anaplastic thyroid carcinoma treated with dabrafenib and trametinib

Elevated serum adiponectin in Alzheimer’s disease as neuroprotective strategy

BiosciAbstracts